|
KMID : 1123920080220010171
|
|
Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 1 p.171 ~ p.175
|
|
|
Effect of Loranthi Ramuluswatet Extract on Macrophages Activation and Th1 Response
|
|
Kim Youn-Chul
Yun Young-Gab
Park Hyun
|
|
|
Abstract
|
|
|
|
In the recently, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the effect of the water extract of Loranthi Ramulus (LR) in production of inflammatory mediators and expression of toll-like receptor (TLR)-4, CD14 from peritoneal macrophage. We assayed the effect of LR water extract in cell proliferation in vitro and Th1/Th2 cytokine level in vivo. In peritoneal macrophages, water extract of LR water extract increased the production of Nitric oxide (NO) and . Also, LR water extract increased Con A-induced cell proliferation and IgG1, IgG2a level in serum. However, i.p. injection of water extract of LR water extract did not affect the level of , , IL-2, IL-4 and IL-5 in serum of mice. These studies indicate that LR water extract induces macrophage activation and suggest the possible use of LR water extract in macrophage-based immunotherapies.
|
|
|
KEYWORD
|
|
|
Loranthi Ramulus , Nitric oxide, TLR4
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|